| Name | Date | Defenses |
| Nehomar Cermeno– Interim | March 14, 2009 — Present | 2 |
| Anselmo Moreno | May 31, 2008 — Present | 4 |
| Poonsawat Kratingdaenggym – Interim | August 31, 2005 — July 15, 2006 | 1 |
| Wladimir Sidorenko– def Julio Zarate | February 26, 2005 — May 31, 2008 | 6 |
| Julio Zarate – Interim | March 6, 2004 — March 13, 2004 | 0 |
| Hideki Todaka – Interim | October 4, 2003 — March 6, 2004 | 0 |
| Johnny Bredahl | April 19, 2002 — February 26, 2005 (retires) | 3 |
| Eidy Moya – Interim | December 16, 2000 — April 19, 2002 | 1 |
| Paulie Ayala | June 26, 1999 — April 19, 2002 | 3 |
| Johnny Tapia | December 5, 1998 — June 26, 1999 | 0 |
| Nana Konadu | June 21, 1997 — December 5, 1998 | 1 |
| Daorung Chuvatana | October 27, 1996 — June 21, 1997 | 1 |
| Nana Konadu | January 28, 1996 — October 27, 1996 | 0 |
| Veeraphol Sahaprom | September 17, 1995 — January 28, 1996 | 0 |
| Daorung Chuvatana | July 16, 1994 — September 17, 1995 | 2 |
| John Michael Johnson | April 22, 1994 — July 16, 1994 | 0 |
| Junior Jones | October 23, 1993 — April 22, 1994 | 1 |
| Jorge Julio Rocha | October 9, 1992 — October 23, 1993 | 2 |
| Eddie Cook | March 15, 1992 — October 9, 1992 | 0 |
| Israel Contreras | October 19, 1991 — March 15, 1992 | 0 |
| Luisito Espinosa | October 18, 1989 — October 19, 1991 | 2 |
| Kaokor Galaxy | July 9, 1989 — October 18, 1989 | 0 |
| Sung-Kil Moon | August 14, 1988 — July 9, 1989 | 2 |
| Kaokor Galaxy | May 9, 1988 — August 14, 1988 | 0 |
| Wilfredo Vazquez | October 4, 1987 — May 9, 1988 | 1 |
| Chan-Yong Park | May 24, 1987 — October 4, 1987 | 0 |
| Takuya Muguruma | March 29, 1987 — May 24, 1987 | 0 |
| Bernardo Pinango | June 4, 1986 — 1987 | 3 |
| Gaby Canizales | March 10, 1986 — June 4, 1986 | 0 |
| Richie Sandoval | April 7, 1984 — March 10, 1986 | 2 |
| Jeff Chandler | November 14, 1980 — April 7, 1984 | 9 |
| Julian Solís | August 29, 1980 — November 14, 1980 | 0 |
| Jorge Luján | November 19, 1977 — August 29, 1980 | 5 |
| Alfonso Zamora | March 14, 1975 — November 19, 1977 | 5 |
| Soo-Hwan Hong | July 3, 1974 — March 14, 1975 | 1 |
| Arnold Taylor | November 3, 1973 — July 3, 1974 | 0 |
| Romeo Anaya | January 20, 1973 — November 3, 1973 | 2 |
| Enrique Pinder | July 29, 1972 — January 20, 1973 | 0 |
| Rafael Herrera | March 19, 1972 — July 29, 1972 | 0 |
| Rubén Olivares | April 2, 1971 — March 19, 1972 | 2 |
| Chucho Castillo | October 16, 1970 — April 2, 1971 | 0 |
| Rubén Olivares | August 22, 1969 — October 16, 1970 | 2 |
| Lionel Rose | February 27, 1968 — August 22, 1969 | 3 |
| Masahiko Harada | May 18, 1965 — February 27, 1968 | 4 |
| Eder Jofre | November 18, 1960 — May 18, 1965 | 8 |
| Jose Becerra | July 8, 1959 — August 30, 1960 | 2 |
| Alphonse Halimi | November 6, 1957 — July 8, 1959 | 0 |
| Raul Macias | March 9, 1955 — November 6, 1957 | 2 |
| Robert Cohen | September 19, 1954 — 1955 | 0 |
| Jimmy Carruthers | November 15, 1952 — May 2, 1954 | 3 |
| Vic Toweel | May 31, 1950 — November 15, 1952 | 3 |
| Manuel Ortiz | March 11, 1947 — May 31, 1950 | 4 |
| Harold Dade | January 6, 1947 — March 11, 1947 | 0 |
| Manuel Ortiz | August 7, 1942 — January 6, 1947 | 14 |
| Lou Salica | September 24, 1940 — August 7, 1942 | 5 |
| Georgie Pace | October 29, 1939 — September 24, 1940 | 0 |
| Sixto Escobar (3) | February 20, 1938 — October 4, 1939 | 1 |
| Harry Jeffra | September 23, 1937 — February 20, 1938 | 0 |
| Sixto Escobar | November 15, 1935 — September 23, 1937 | 3 |
| Lou Salica | August 26, 1935 — November 15, 1935 | 0 |
| Sixto Escobar | August 7, 1935 — August 26, 1935 | 0 |
| Panama Al Brown | June 18, 1929 — April 1935 | 6 |
| Bud Taylor | June 24, 1927 — January 24, 1928 | 0 |
| Charley Rosenberg | March 20, 1925 — 1927 | 2 |
| Eddie Martin | December 19, 1924 — March 20, 1925 | 2 |
| Abe Goldstein | March 21, 1924 — December 19, 1924 | 4 |
| Joe Lynch | December 22, 1922 — March 21, 1924 | 1 |